Wednesday 15 November 2017

Carboxymethyl Cellulose Integral to Drug Manufacturing Process

Cellulose fibers have multiple roles as thickening and mixing agents in various sectors. Rising preference for the products made from naturally-derived ingredients is expected to result in immense demand for carboxymethyl cellulose.


What is Carboxymethyl Cellulose?

Carboxymethyl cellulose (CMC) is a cellulose derivative used as a thickener or stabilizer. Its sodium salt derivative, sodium carboxymethyl cellulose is utilized as a food additive and is deemed safe by the US Food & Drug Administration (FDA). Sodium CMC finds applications in the ice cream industry as an adhesive to stop the ice creams from separating.

Other significant industries using CMC include paper & pulp, oil & gas, pharmaceutical, and medical. The rise in offshore shale exploration activities in the US is expected to drive the demand for carboxymethyl cellulose in North America. Research into its properties has even led to its usage in thermoplastics.

Injection Molding

Rayonier Performance Fibers collaborated with the USDA Forest Products Laboratory to manufacture thermoplastics using cellulose-based fibers. The company registered a patent for compressing cellulose fibers into pellets. It uses a mixture of wet pulp and sodium CMC to produce pellets. These pellets are then melt compounded to produce pellets for injection molding.

Drug Manufacturing

The medical sector has recognized the benefits of carboxymethyl cellulose as an excipient in the drug manufacturing process. It is added to the Active Pharmaceutical Ingredient (API) in drugs to provide moisture during extreme temperatures. In addition, researchers have developed microneedles to deliver drugs for the less invasive drug delivery methods. These dissolvable microneedles are made from CMC and layered double hydroxide nanoparticles.

Market Overview

The worldwide carboxymethyl cellulose market is expected at nearly USD 1.9 billion by 2025, according to Grand View Research, Inc. It stood at USD 1.2 billion in 2016. The market is anticipated to grow at a significant CAGR over the forecast period (2014 to 2025). High demand for eco-friendly products is the key market driver. Advances in CMC manufacturing is expected to further support market growth in the forthcoming years.

In 2016, food & beverage led the global market owing to widespread applications as a stabilizer in bakery products. It is expected to display a 5.3% CAGR over the forecast period. Asia Pacific accounted for nearly 41% demand share in 2016. It may continue exhibiting a robust CAGR till 2025. Prominent market players are Daicel FineChem Ltd., The Dow Chemical Company, Nippon Paper Industries Co., Ltd., and Akzo Nobel N.V.

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1 comment:

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